Are you meaning the seal between double glazing and rebate / timber glazing bead?
The silicone used to seal in the double glazing should be low modulus silicone, or neutral cure.
If there is sealant needed between beading and sash rebate or a small visible sealant bead where glass meets the beading, which may be overpainted at some time, I would use either MS polymer which is an over paintable silicone or repair care dryseal glazing sealant.