The biggest prob is getting in to the corner where the narrow part meets the taper on the stile. Whatever tooling, hand or machine, you are going to have to finish off by hand with sharp chisels and carve/pare your way in.
One of the rare occasions where a router could be the best tool as the small radius lets you close up to the angle.
The next prob is the taper on the rail - this is best machined with a margin for error and then fitted by finishing with a shoulder plane. So the tenons have to be an easy push fit to enable you to do a series of trial fits.
You machine ALL the mortices before you do the reduced stile, whilst its all still in the square, unless you are doing them by hand.
And of course you need immaculate marking out and rod - all done with 2H pencil.
The rebate/moulding on the narrow part MUST be to the same depth or you will need to make slightly different angled tapers front and back - not impossible, just twice as difficult! Or you can make it a lot easier by not moulding/rebating at all, and planting on a bead to make a glazing rebate afterwards.
cheers
Jacob