There used to be an excellent (and at the time, free) article by someone called Hislop about the design of DG windows, discussing practice from all round the world, especially USA, Germany and Scandinavia, where they regularly have much more severe weather than we have traditionally had here.
When I did my windows in my last house, I followed his best practice advice, which I'll try to précis.
There should be a 3mm air gap around all 4 edges. This air gap should be vented rather than sealed.
This is achieved by sitting the unit on two or three packers, which are the full depth of the rebate, so they end up flush with the outside face. This is important.
The rebate is painted before the glass is installed, then a generous squirt of glazing sealant applied to the rebate. The DG unit is pressed hard into the silicone so that there is squeeze-out. Painted beading then has a generous bead of silicone applied and is pressed into place along the top and both sides, so that again, there is squeeze-out. This is to prevent water getting in between the beading and the glass, causing damage and looking unsightly from the inside.
Finally the bottom bead is applied. This is L-shaped with the short arm of the L acting as a drip strip over the bottom edge. It is pinned into place through the packers, so that there is an air gap underneath it. The result is a unit that can move but is sealed from water, but can drain (under that lower bead) and is ventilated so that water does not accumulate either by rain or condensation.
The silicone sealant is trimmed flush when cured.
I wasn't in the house long enough to tell you what the lifespan was like, but when I told the glazing supplier how I was doing it he commented that it was a Rolls-Royce job and if he were doing his own house, that is how he would do it.
If you can find it online, the Hislop paper is a good read.
HTH
S