I have a steb centre (the one that fits in a chuck) and it's useful but I fairly regularly find, particularly when roughing down from square, that the wood starts to slip and I end up having to tighten the tail stock. Once this has started it usually continues and the steb centre teeth cut a ring in the wood. Once this ring gets to the full depth of the teeth it's not possible to tighten any more and I have to reverse the blank.
When not using the steb centre I tend to go with the 2 prong drive and occasionally the 4 prong. Not sure why 2 prong over 4 but it just seems to be that way. It's certainly better when working with blanks cut from logs when the surface isn't flat. In the 4+ years that I've been using the 2 prong I've never had anything split due to the chiselling effect mentioned and I've never had anything come off the lathe. I'm not saying that this is best practice and what beginners should do, just relating my experience. If I turned more shop bought, square cut spindle blanks then I'd probably stick with 4 prong.
When turning rough cut blanks I also sometimes drill a hole and use the chuck pin jaws in expansion mode.